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Border Collies are the cleverest dogs most of us will ever live with, and that intelligence cuts both ways. A Collie without enough to do gets anxious, obsessive and noise-sensitive, and no supplement fixes a bored working brain. Calming products help, but only alongside proper mental and physical exercise.
That caveat matters more for this breed than almost any other. Get the routine right first, then use a supplement to take the edge off.
The herding instinct doesn't switch off in a living room. Collies fixate on movement, flickering light, cars, other dogs, and can spiral into anxious, repetitive behaviour when understimulated. A calming supplement can lower the baseline tension, which makes training and settling easier, but it works with enrichment, not instead of it.
One breed-specific caution: some Collies carry the MDR1 gene mutation, which affects how they process certain drugs. It's about medication rather than supplements, but it's a good reason to always check with your vet before giving a Collie anything new.

A sensible daily calmer with l-tryptophan and lemon balm. Best for background, everyday tension rather than acute panic.
Check Price on Amazon →Alpha-casozepine, derived from a milk protein. Vets reach for this around predictable stress like fireworks or a house move. Capsules open over food.
Check Price on Amazon →Fast-acting, for one-off stressful events. Worth keeping in for New Year's Eve.
Check Price on Amazon →Not a supplement but worth pairing. A valerian plug-in or spray for the room takes the edge off the environment.
Check Price on Amazon →I'll say it plainly because it's true for this breed above all: a Collie that's exercised, trained and given a job is calmer than any supplement can make a bored one. Sort the lifestyle, then let the supplement help at the margins.

They can lower general anxiety and help a Collie settle, but only alongside enough physical and mental exercise. For an understimulated Collie, enrichment does more than any supplement.
For daily tension, YuMOVE Calming Care or a tryptophan-based product. For predictable events like fireworks, Zylkene or a fast-acting option like Nutracalm.
Often both. Boredom and anxiety look similar in this breed, pacing, obsessive behaviours, reactivity. More structured exercise and training usually helps before you judge whether a supplement is needed.