This page contains affiliate links. As an Amazon Associate we earn from qualifying purchases — at no extra cost to you.

Cats are creatures of habit, and stress in a cat often shows up as behaviour we misread: spraying, overgrooming, hiding, hissing at a housemate cat, or a litter tray protest. A new baby, a house move, building work or a new cat next door can all set it off. Calming products can genuinely help, though the environment usually matters more.
The evidence is decent for a couple of specific ingredients in cats, which is more than can be said for many pet calming products.
Cats hate change and hate competition over resources. In multi-cat homes a lot of 'behaviour problems' are really stress over food bowls, litter trays and territory. Fixing that, more trays, more separate feeding spots, vertical space, does more than any supplement. Then a calming product can help take the residual edge off.
Two ingredients have reasonable support in cats: alpha-casozepine (the milk-protein derivative in Zylkene) and l-theanine. Pheromone diffusers like Feliway aren't supplements but pair well and are worth trying alongside.

Alpha-casozepine from a milk protein, with reasonable evidence in cats. Good for predictable stress like a move or a vet visit. Capsules sprinkle over food.
Check Price on Amazon →Not a supplement but a proven pairing. A pheromone plug-in that helps cats feel the space is safe, especially in multi-cat homes.
Check Price on Amazon →A daily calming supplement for cats with everyday anxiety.
Check Price on Amazon →A budget pheromone option and calming range, worth trying for milder stress.
Check Price on Amazon →With cats especially, the environment does most of the work. Rule of thumb for multi-cat homes: one litter tray per cat plus one spare, separate feeding spots, and plenty of high perches and hiding places. Get that right and a calming supplement has far less to do.

Some do. Alpha-casozepine and l-theanine have reasonable evidence in cats. They work best alongside environmental changes, not instead of them.
For predictable stress like a move or vet trip, Zylkene is a solid choice. Pair it with a Feliway diffuser for the environment. Use cat-specific products only.
It might help, but these are stress signals worth investigating. Look at resources and changes in the home, and see a vet to rule out medical causes such as urinary or skin problems.